Pesticide resistance is an example of “survival of the fittest” — those pests that develop a resistance to a pesticide are better able to survive exposure. This article walks growers through how they can better manage pesticide resistance by, for example, not relying on a single pesticide mode-of-action, integrating cultural and biological controls as part of their pest management practices, using pesticides at label-recommended rates and never re-treating with the same pesticide if it fails the first time.